By Rodrick Wallace,Deborah Wallace
This publication, in keeping with released reports, takes a different viewpoint at the 30-year cave in of pharmaceutical productiveness within the look for small molecule “magic bullet” interventions. The relentless escalation of inflation-adjusted rate consistent with licensed drugs within the usa — from $200 million in 1950 to $1.2 billion in 2010 — has pushed giants to, at top, slavish imitation in drug layout, and at worst, abandonment of study and embracing of frequent fraud in client marketing.
The ebook adapts formalism throughout a few disciplines to the tactic for layout of mutilevel interventions, focusing first on molecular, mobile, and bigger scale examples, after which extending the argument to the simplifications supplied via the dominant function of social and cultural constructions and procedures in person and inhabitants styles of health and wellbeing and illness.
In position of “magic bullets”, we needs to now practice “magic options” that act throughout either the dimensions and point of association. This booklet offers an introductory roadmap to the recent instruments that might be wanted for the layout of such strategies.
- Beyond Magic Bullets
- Expanding the Theory
- Dynamic ‘Regression Models’
- An Evolutionary Excursion
- Example: psychological Disorders
- Example: Protein Folding
- Example: Glycome Determinants
- Example: Glycan/Lectin common sense Gates
- Example: IDP common sense Gates
- History and Health
- Beyond Glasperlenspiel
- Mathematical Appendix
Readership: Undergraduate, graduate, researchers and pros in biomathematics, biostatistics, mathematical modeling, complicated platforms and pharmaceuticals.
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Additional info for A Mathematical Approach to Multilevel, Multiscale Health Interventions:Pharmaceutical Industry Decline and Policy Response
A Mathematical Approach to Multilevel, Multiscale Health Interventions:Pharmaceutical Industry Decline and Policy Response by Rodrick Wallace,Deborah Wallace